Buy Cheap All-Natural Chicago Phase 2 Gastrointestinal Detox Anti-Aging Herbal Supplements Vitamins
Why pick our Natural Phase 2 Gastrointestinal Detox Herbal Supplement?
There are many options available today when choosing vitamins and anti-aging supplements. This means that you have to be careful as a consumer and make sure you choose a reliable manufacturer who only uses the highest quality ingredients. The Chicago Center For Anti-Aging has partnered with one of the most reputable manufacturers which helps ensure the quality of our private line of vitamins and anti-aging supplements. Quality is what should be the most important attribute you should look for to help make your decision, not cost. Look for quality you can trust.
Whole Grain Brown Rice Sweetener and Natural Flavors
Core Support was created as part of The Core Restore BT Kit. Core Restore supports phase II detoxification by providing proteins, fiber, and nutrients to help eliminate toxins during a 7-28 day detoxification program. This product is an improvement on similar products that have been a mainstay in detoxification protocols for more than a decade.
Overview of Detoxification:
• Few clinical studies have been done in humans on the detoxification process. There is limited research on the selected nutrients and associated detoxification pathways.
• There are two main pathways of detoxification in the liver, known as phase I and phase II. In phase I, non-reactive compounds undergo specific reactions which use oxygen to form a reactive site on the compound. This new intermediary metabolite must then undergo a phase II reaction, which results in the addition of a water soluble group to the reactive site. The end result is a compound that is now able to be excreted in the urine, bile, or stool.1
• The phase I detoxification pathway is mainly composed of the cytochrome P450 family of enzymes.2
• Proper function of both phases is essential for detoxification. Increased phase I activity and or decreased phase II activity has been associated with an increased risk of health related issues.2
• Some nutrients have been found to play supportive roles in the detoxification pathways including: flavonoids, amino acids, glycine, taurine, NAC, and many vitamins and minerals.1
• NAC is a sulfhydryl containing (contains sulfur and hydrogen) compound that is commonly used to support liver health. Because of this sulfhydryl activity, NAC stimulates glutathione production and is used in one of the 6 phase II detoxification pathways called glutathione conjugation (the attachment of glutathione to the toxin).3
• In vivo studies show that NAC has direct effects on certain mutagenic/carcinogenic toxins that prevents them from converting to more toxic substances.4
• One of the 6 phase II detoxification pathways is amino acid conjugation (the attachment of amino acids to the toxin). Glycine is one of the amino acids used in this process. Glycine also aids in glutathione conjugation.1
• One of the 6 phase II detoxification pathways is sulfation (the attachment of sulfur-containing compounds to the toxin). Taurine provides a good source of sulfur.5
• Taurine has direct detoxification properties with specific substances such as endotoxins, carbon tetrachloride, and
• Taurine is commonly used to support liver health. Studies show taurine effectively conjugates bile acids and is often used in
• Lipoic acid is a potent antioxidant. Lipoic acid increases glutathione, vitamin E, and vitamin C levels in the body.6
• In vitro, lipoic acid induced the upregulation of phase II detoxification enzymes including NAD(P)H,quinine oxidoreductase, and glutathione-S-transferase.7
• Lipoic acid has been used to detox mycotoxins (toxic byproducts of fungi and molds). Some mycotoxins have been found to mimic xenobiotics in their destructive effects on the body and in their routes of detoxification.8
Green Tea Extract:
• Green tea extract is a potent antioxidant that has phase II stimulating properties. Green tea also contains high levels of beneficial polyphenols.
• In vivo studies have shown that green tea extract increases phase II enzymes such as glutathione S-transferases, NAD(P)H:quinine reductases, epoxide hydrolases, and UDP-glucuronosyltransferases.9
• Rosemary contains polyphenols that are potent antioxidants and also have anticarcinogenic properties.10
• Two principle mechanisms have been found in the detoxification actions of rosemary. One, it inhibits the metabolic activation of procarcinogens catalysed by the phase I cytochrome P450 enzymes and two, it induces phase II enzymes.10,1
• Ellagic acid is a polyphenol found naturally in plants such as grapes, pomegranates and raspberries.
• Ellagic acid has been found to induce phase II detoxification enzymes.11,12,13
Vegetable Antioxidant Blend:
• VitaVeggie® is a blend of broccoli powder, broccoli sprout extract, tomato powder, carrot powder, spinach powder, kale powder, brussel sprout powder, and onion extract. It is high in ORAC value and also contains sulphoraphane and glucosinolates.
• In an in vitro study, VitaVeggie® stimulated quinine reductase, the most recognized enzyme belonging to the phase II detoxifying proteins group.14
• Cruciferous vegetables including broccoli, kale, and brussel sprouts increase the enzyme activity of both phase I and phase II detoxification.15
• Sulforaphane has been shown to activate phase II detoxification enzymes in vitro.16
• It is believed that one of the main anticarcinogenic benefits of fruits and vegetables is due to the increase of phase II detoxification enzymes.1,17
Schizandra Berry Extract:
• In animal studies, Schizandra enhances liver detoxification pathways by increasing liver reduced glutathione levels as well as glutathione reductase and glutathione S-transferase activity.18
• Psyllium husk is from the plant Plantago ovata and largely used for its fiber content. Psyllium husk contains a large amount of soluble fiber per volume. Psyllium is used to improve GI transit time, in GI related health issues, and for cardiovascular support.
• Studies show psyllium husk powder upregulates genes involved in bile acid synthesis and binds to bile-acids in the intestines to gently remove them from the body.19,20
As a dietary supplement, mix 2 scoops (40.18g) of Core Support with 8 oz. of water or the beverage of your choice 2 times
Contraindications, Adverse or Other Reactions
Do not take this product if you are pregnant or nursing. NOTICE: Without drinking enough liquid, this product may swell in throat, causing blockage or choking.
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1. Liska, D. J. The detoxification enzyme systems. Altern Med Rev. 1998; 3(3):187-198.
2. Liska, D., Lyon, M. et al. Detoxification and Biotransformational Imbalances. 2005;(22):275-298.
3. Kelly, G. S. Clinical applications of N-acetylcysteine. Altern Med Rev. 1998; 3(2):114-127.
4. De, Flora S., Bennicelli, C. et al. In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds.
Carcinogenesis. 1985; 6(12):1735-1745.
5. Birdsall, T. C. Therapeutic applications of taurine. Altern Med Rev. 1998; 3(2):128-136.
6. Smith, A. R., Shenvi, S. V. et al. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 2004; 11(9):1135-1146.
7. Flier, J., Van Muiswinkel, F. L. et al. The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. Free Radic Res. 2002; 36(6):695-699.
8. Rogers, S. A. Lipoic acid as a potential first agent for protection from mycotoxins and treatment of mycotoxicosis. Arch Environ Health. 2003; 58(8):528-532.
9. Yu, R., Jiao, J. J. et al. Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive elementmediated
phase II enzyme gene expression. Carcinogenesis. 1997; 18(2):451-456.
10. Offord, E. A., Mace, K. et al. Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells.
Cancer Lett. 1997; 114(1-2):275-281.
11. Barch, D. H., Rundhaugen, L. M. et al. Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene. Carcinogenesis. 1995; 16(3):665-668.
12. Barch, D. H., Rundhaugen, L. M. et al. Structure-function relationships of the dietary anticarcinogen ellagic acid. Carcinogenesis. 1996; 17(2):265-269.
13. Girish, C. and Pradhan, S. C. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. Fundam Clin Pharmacol. 2008; 22(6):623-632.
14. VDF FutrueCeuticals R&D Department. VitaVeggie is a potent activator of Quinone Reductase in vitro. 2000;
15. Nestle, M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci U S A. 1997; 94(21):11149-11151.
16. Bacon, J. R., Williamson, G. et al. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes.
Carcinogenesis. 2003; 24(12):1903-1911.
17. Talalay, P. and Fahey, J. W. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr. 2001; 131(11 Suppl):3027S-3033S.
18. Ip, S. P., Mak, D. H. et al. Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats. Pharmacol Toxicol.
19. Chan, M. Y. and Heng, C. K. Sequential effects of a high-fiber diet with psyllium husks on the expression levels of hepatic genes and plasma lipids. Nutrition. 2008; 24(1):57-66.
20. Burton, R. and Manninen, V. Influence of a psyllium-based fibre preparation on faecal and serum parameters. Acta Med Scand Suppl. 1982; 668:91-94.
** Information for health care professionals only.
** These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent, or cure any disease. Consult a physician before taking. Should you experience any serious physical side effects from taking these nutritional supplements, discontinue and call your doctor immediately.